Details of Metabolite
Full List of Protein(s) Regulating This Metabolite | ||||||
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GPCR secretin (GPCR-2) | ||||||
Glucagon receptor (GCGR) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[1] | ||||
Introduced Variation | Knockout of Gcgr | |||||
Induced Change | Fructose concentration: decrease (FC = 1.4) | |||||
Summary | Introduced Variation
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Disease Status | Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
Details | It is reported that knockout of GCGR leads to the decrease of fructose levels compared with control group. | |||||
Hydrolases (EC 3) | ||||||
Alpha-N-acetylglucosaminidase (NAGLU) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[2] | ||||
Introduced Variation | Knockout of Naglu | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Lysosomal storage diseases [ICD-11: 5C56] | |||||
Details | It is reported that knockout of Naglu leads to the decrease of fructose levels compared with control group. | |||||
Sugar transporter (ST) | ||||||
Glucose transporter type 14 (GLUT-14) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[3] | ||||
Introduced Variation | Overexpression of SLC2A14 | |||||
Induced Change | Fructose concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Inflammatory bowel disease [ICD-11: DD72] | |||||
Details | It is reported that overexpression of SLC2A14 leads to the increase of fructose levels compared with control group. | |||||
Glucose transporter type 2 (GLUT-2) | Click to Show/Hide the Full List of Regulating Pair(s): 3 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair (1) |
Experim Info
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[4] | ||||
Introduced Variation | Mutation (I322V) of SLC2A2 | |||||
Induced Change | Fructose concentration: decrease (FC = 0.60) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (I322V) of SLC2A2 leads to the decrease of fructose levels compared with control group. | |||||
Regulating Pair (2) |
Experim Info
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[5] | ||||
Introduced Variation | Mutation (p.277-279 HVA>QLS) of SLC2A2 | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (p.277-279 HVA>QLS) of SLC2A2 leads to the decrease of fructose levels compared with control group. | |||||
Regulating Pair (3) |
Experim Info
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[5] | ||||
Introduced Variation | Overexpression of SLC2A2 | |||||
Induced Change | Fructose concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLC2A2 leads to the increase of fructose levels compared with control group. | |||||
Glucose transporter type 3 (GLUT-3) | Click to Show/Hide the Full List of Regulating Pair(s): 2 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair (1) |
Experim Info
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[5] | ||||
Introduced Variation | Mutation (p.277-279 HVA>QLS) of SLC2A3 | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (p.277-279 HVA>QLS) of SLC2A3 leads to the decrease of fructose levels compared with control group. | |||||
Regulating Pair (2) |
Experim Info
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[6] | ||||
Introduced Variation | Knockdown (siRNA) of SLC2A3 | |||||
Induced Change | Fructose concentration: decrease (FC = 0.72) | |||||
Summary | Introduced Variation
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Disease Status | Insulin-resistance syndromes [ICD-11: 5A44] | |||||
Details | It is reported that knockdown of SLC2A3 leads to the decrease of fructose levels compared with control group. | |||||
Glucose transporter type 5 (GLUT-5) | Click to Show/Hide the Full List of Regulating Pair(s): 2 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair (1) |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLC2A5 | |||||
Induced Change | Fructose concentration: increase (FC = 8 - 9) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLC2A5 leads to the increase of fructose levels compared with control group. | |||||
Regulating Pair (2) |
Experim Info
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[7] | ||||
Introduced Variation | Mutation (I296V) of SLC2A5 | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (I296V) of SLC2A5 leads to the decrease of fructose levels compared with control group. | |||||
Glucose transporter type 7 (GLUT-7) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[7] | ||||
Introduced Variation | Mutation (I314V) of SLC2A7 | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (I314V) of SLC2A7 leads to the decrease of fructose levels compared with control group. | |||||
Glucose transporter type 9 (GLUT-9) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLC2A9 | |||||
Induced Change | Fructose concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLC2A9 leads to the decrease of fructose levels compared with control group. | |||||
HepG2 glucose transporter (SLC2A1) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[6] | ||||
Introduced Variation | Knockdown (siRNA) of SLC2A1 | |||||
Induced Change | Fructose concentration: decrease (FC = 0.65) | |||||
Summary | Introduced Variation
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Disease Status | Insulin-resistance syndromes [ICD-11: 5A44] | |||||
Details | It is reported that knockdown of SLC2A1 leads to the decrease of fructose levels compared with control group. | |||||
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