| Regulating Pair |
| Introduced Variation |
Mutation (p.277-279 HVA>QLS) of SLC2A2 |
Protein Info
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| Induced Change |
Fructose concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of D-fructose concentration after SLC2A2 mutation (p.277-279 HVA>QLS) through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus laevis oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (p.277-279 HVA>QLS) of SLC2A2 leads to the decrease of fructose levels compared with control group in xenopus laevis oocytes. |
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| References |
| 1 |
QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998 Feb 3;37(5):1322-6.
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