Details of Experiment

Regulating Pair
Introduced Variation	Knockdown (siRNA) of SLC2A3	Protein Info
Induced Change	Fructose concentration: decrease (FC = 0.72)	Metabo Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the change of D-fructose concentration after SLC2A3 knockdown through kit detection.
Disease Status	Insulin-resistance syndromes	ICD-11: 5A44
Organ/Tissue/Cell Line	HUVEC cells (Human Umbilical Vein Endothelial cells)	Umbilical cord
Subcellular Location	Membrane (Cell membrane); Cytoplasm (Perikaryon); Cell projection
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that knockdown of SLC2A3 leads to the decrease of fructose levels compared with control group in HUVEC cells.

References
1	Transendothelial glucose transport is not restricted by extracellular hyperglycaemia. Vascul Pharmacol. 2016 Dec;87:219-229.

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