Details of Metabolite

General Information of MET (ID: META00735)
Name 2-Deoxyglucose
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2 Deoxy D glucose; 2 Deoxyglucose; 2 Desoxy D glucose; 2-Deoxy-D-arabino-hexose; 2-Deoxy-D-glucose; 2-Deoxy-D-mannose; 2-Desoxy-D-glucose; D-2DGLC; D-Arabino-2-deoxyhexose; Deoxyglucose
Source Aliphatic acyclic compounds
Structure Type   Fatty alcohols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty alcohols
PubChem CID
108223
HMDB ID
HMDB0062477
Formula
C6H12O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB08831
ChEBI ID
15866
ChemSpider ID
97292
Physicochemical Properties Molecular Weight 164.16 Topological Polar Surface Area 98
XlogP -2.9 Complexity 116
Heavy Atom Count 11 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
2-Deoxyglucose is classified as a member of the fatty alcohols. Fatty alcohols are aliphatic alcohols consisting of a chain of a least six carbon atoms. 2-Deoxyglucose is considered to be soluble (in water) and acidic.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Growth factor (GF)
            Transforming growth factor beta 1 (TGFB1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of TGFB1
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Brain cancer [ICD-11: 2A00]
                      Details It is reported that recombinant protein addition of TGFB1 leads to the increase of 2-deoxyglucose levels compared with control group.
      Nuclear hormone receptor (NHR)
            PPAR-gamma (PPARG) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Agonist (apo-12'-lycopenal) of PPARG
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that agonist of PPARG leads to the increase of 2-deoxyglucose levels compared with control group.
      Sugar transporter (ST)
            Glucose transporter type 10 (GLUT-10) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of SLC2A10
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that overexpression of SLC2A10 leads to the increase of 2-deoxyglucose levels compared with control group.
            Glucose transporter type 2 (GLUT-2) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Mutation (p.277-279 HVA>QLS) of SLC2A2
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (p.277-279 HVA>QLS) of SLC2A2 leads to the increase of 2-deoxyglucose levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of SLC2A2
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC2A2 leads to the increase of 2-deoxyglucose levels compared with control group.
            Glucose transporter type 3 (GLUT-3) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [4], [3]
                      Introduced Variation Overexpression of SLC2A3
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual ...
                      Details It is reported that overexpression of SLC2A3 leads to the increase of 2-deoxyglucose levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Mutation (p.277-279 HVA>QLS) of SLC2A3
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (p.277-279 HVA>QLS) of SLC2A3 leads to the increase of 2-deoxyglucose levels compared with control group.
            Glucose transporter type 4 (GLUT4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of SLC2A4
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that overexpression of SLC2A4 leads to the increase of 2-deoxyglucose levels compared with control group.
            Glucose transporter type 8 (GLUT-8) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [5]
                      Introduced Variation Mutation (di-leucine to di-alanine substitution (LL-AA)) of Slc2a8
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (di-leucine to di-alanine substitution (LL-AA)) of Slc2a8 leads to the increase of 2-deoxyglucose levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [5]
                      Introduced Variation Overexpression of Slc2a8
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Slc2a8 leads to the increase of 2-deoxyglucose levels compared with control group.
            HepG2 glucose transporter (SLC2A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [5]
                      Introduced Variation Overexpression of SLC2A1
                      Induced Change 2-Deoxyglucose concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC2A1 leads to the increase of 2-deoxyglucose levels compared with control group.
References
1 TGF-1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells. FEBS J. 2017 Oct;284(20):3437-3454.
2 Apo-12&#39;-lycopenal, a Lycopene Metabolite, Promotes Adipocyte Differentiation via Peroxisome Proliferator-Activated Receptor Activation. J Agric Food Chem. 2018 Dec 19;66(50):13152-13161.
3 Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. Sep-Oct 2001;74(1-2):186-99.
4 QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998 Feb 3;37(5):1322-6.
5 Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem. 2013 Mar 29;288(13):9092-101.

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