| Regulating Pair |
| Introduced Variation |
Overexpression of SLC2A4 |
Protein Info
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| Induced Change |
2-Deoxyglucose concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 2-deoxyglucose concentration after SLC2A4 overexpression through C14-labeled amino acids kit detection. |
| Disease Status |
Type 2 diabetes mellitus |
ICD-11: 5A11 |
| Organ/Tissue/Cell Line |
Xenopus oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane; Endomembrane system); Cytoplasm (Perinuclear region) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC2A4 leads to the increase of 2-deoxyglucose levels compared with control group in xenopus oocytes. |
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| References |
| 1 |
Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. Sep-Oct 2001;74(1-2):186-99.
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