Details of Experiment

Regulating Pair
       Introduced Variation Overexpression of SLC2A3 Protein Info
       Induced Change 2-Deoxyglucose concentration: increase Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment (1) for Validating Pair [1]
       Method Quantifying the change of 2-deoxyglucose concentration after SLC2A3 overexpression through C14-labeled amino acids kit detection.
       Disease Status Healthy individual
       Organ/Tissue/Cell Line Xenopus laevis oocytes N.A.
       Subcellular Location Membrane (Cell membrane); Cytoplasm (Perikaryon); Cell projection
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC2A3 leads to the increase of 2-deoxyglucose levels compared with control group in xenopus oocytes.
Details of Experiment (2) for Validating Pair [2]
       Method Quantifying the change of 2-deoxyglucose concentration after SLC2A3 overexpression through C14-labeled amino acids kit detection.
       Disease Status Type 2 diabetes mellitus ICD-11: 5A11
       Organ/Tissue/Cell Line Xenopus oocytes N.A.
       Subcellular Location Membrane (Cell membrane); Cytoplasm (Perikaryon); Cell projection
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that overexpression of SLC2A3 leads to the increase of 2-deoxyglucose levels compared with control group in xenopus oocytes.
References
1 QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 position of D-glucose and is involved in substrate selection at the exofacial binding site. Biochemistry. 1998 Feb 3;37(5):1322-6.
2 Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. Sep-Oct 2001;74(1-2):186-99.

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