Details of Metabolite

General Information of MET (ID: META00105)
Name Tetracycline
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(4S,4AS,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide; Abramycin; Achromycin; Anhydrotetracycline; Deschlorobiomycin; Liquamycin; Sumycin; TC; Tetracyclin; Tetracycline HCL; Tetracyclinum; Tetrazyklin; Tsiklomitsin
Source Drug
Structure Type   Tetracyclines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Tetracyclines
HMDB ID
HMDB0014897
Formula
C22H24N2O8
Structure
2D MOL
KEGG ID
C06570
DrugBank ID
DB00759
ChEBI ID
27902
ChemSpider ID
10257122
Function
Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some extent to the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular components to leak from bacterial cells.
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Cyclin-related protein (CRP)
            CDK inhibitor 1B p27Kip1 (CDKN1B) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Tetracycline addition (12 hours)
                      Induced Change CDKN1B protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that tetracycline addition causes the decrease of CDKN1B protein expression compared with control group.
      Hydrolases (EC 3)
            Phosphoserine phosphatase (PSPH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Tetracycline addition (96 hours)
                      Induced Change PSPH protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that tetracycline addition causes the decrease of PSPH protein expression compared with control group.
      Oxidoreductases (EC 1)
            Phosphoglycerate dehydrogenase (PHGDH) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Tetracycline addition (24 hours)
                      Induced Change PHGDH protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that tetracycline addition causes the decrease of PHGDH protein expression compared with control group.
      Transferases (EC 2)
            Phosphoserine aminotransferase (PSAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Tetracycline addition (72 hours)
                      Induced Change PSAT1 protein expression levels: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that tetracycline addition causes the decrease of PSAT1 protein expression compared with control group.
Full List of Protein(s) Regulating This Metabolite
      Organic ion transporter (OIT)
            Organic anion transporter 1 (OAT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A6
                      Induced Change Tetracycline concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A6 leads to the increase of tetracycline levels compared with control group.
            Solute carrier family 22 member 11 (SLC22A11) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A11
                      Induced Change Tetracycline concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A11 leads to the increase of tetracycline levels compared with control group.
            Solute carrier family 22 member 7 (SLC22A7) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A7
                      Induced Change Tetracycline concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A7 leads to the increase of tetracycline levels compared with control group.
            Solute carrier family 22 member 8 (SLC22A8) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A8
                      Induced Change Tetracycline concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A8 leads to the increase of tetracycline levels compared with control group.
References
1 cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 2015 Apr;25(4):429-44.
2 Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.

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