| Regulating Pair |
| Introduced Variation |
Overexpression of SLC22A8 |
Protein Info
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| Induced Change |
Tetracycline concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of tetracycline concentration after SLC22A8 overexpression through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
PTCs cells (Proximal tubular cells |
Proximal tubular |
| Subcellular Location |
Membrane (Basolateral cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC22A8 leads to the increase of tetracycline levels compared with control group in PTCs cells. |
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| References |
| 1 |
Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
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