Details of Protein
| General Information of Protein (ID: PRT01602) | |||||
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| Name | Phosphoserine phosphatase (PSPH) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
PSP; PSPase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; PSPH
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| Gene Name | PSPH | Gene ID | |||
| UniProt ID | |||||
| Family | Hydrolases (EC 3) | ||||
| EC Number | EC: 3.1.3.3 (Click to Show/Hide the Complete EC Tree) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MVSHSELRKLFYSADAVCFDVDSTVIREEGIDELAKICGVEDAVSEMTRRAMGGAVPFKA
ALTERLALIQPSREQVQRLIAEQPPHLTPGIRELVSRLQERNVQVFLISGGFRSIVEHVA SKLNIPATNVFANRLKFYFNGEYAGFDETQPTAESGGKGKVIKLLKEKFHFKKIIMIGDG ATDMEACPPADAFIGFGGNVIRQQVKDNAKWYITDFVELLGELEE |
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| Structure | |||||
| Function | Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Glutamine | Click to Show/Hide the Full List of Regulating Pair(s): 2 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair (1) |
Experim Info
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[1] | ||||
| Introduced Variation | Glutamine decrease (48 hours) | |||||
| Induced Change | PSPH protein expression levels: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] ... | |||||
| Details | It is reported that glutamine decrease causes the increase of PSPH protein expression compared with control group. | |||||
| Regulating Pair (2) |
Experim Info
click to show the details of experiment for validating this pair
|
[1] | ||||
| Introduced Variation | Glutamine decrease (48 hours) | |||||
| Induced Change | PSPH mRNA levels: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] ... | |||||
| Details | It is reported that glutamine decrease causes the increase of PSPH mRNA levels compared with control group. | |||||
| Organic oxygen compounds | ||||||
| Glucose | Click to Show/Hide the Full List of Regulating Pair(s): 2 Pair(s) | |||||
| Detailed Information |
Metabo Info
click to show the details of this metabolite
|
|||||
| Regulating Pair (1) |
Experim Info
click to show the details of experiment for validating this pair
|
[1] | ||||
| Introduced Variation | Glucose decrease (48 hours) | |||||
| Induced Change | PSPH protein expression levels: increase | |||||
| Summary | Introduced Variation
Induced Change
|
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| Disease Status | Cervical Cancer [ICD-11: 2C77] ... | |||||
| Details | It is reported that glucose decrease causes the increase of PSPH protein expression compared with control group. | |||||
| Regulating Pair (2) |
Experim Info
click to show the details of experiment for validating this pair
|
[1] | ||||
| Introduced Variation | Glucose decrease (48 hours) | |||||
| Induced Change | PSPH mRNA levels: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] ... | |||||
| Details | It is reported that glucose decrease causes the increase of PSPH mRNA levels compared with control group. | |||||
| Phenylpropanoids and polyketides | ||||||
| Tetracycline | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
click to show the details of this metabolite
|
|||||
| Regulating Pair |
Experim Info
click to show the details of experiment for validating this pair
|
[1] | ||||
| Introduced Variation | Tetracycline addition (96 hours) | |||||
| Induced Change | PSPH protein expression levels: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Acute lymphoblastic leukemia [ICD-11: 2B33] | |||||
| Details | It is reported that tetracycline addition causes the decrease of PSPH protein expression compared with control group. | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 2015 Apr;25(4):429-44. | ||||
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