Details of Experiment

Regulating Pair
Introduced Variation	Tetracycline addition (24 hours)	Metabo Info
Induced Change	PHGDH protein expression levels: decrease	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of PHGDH protein abundances after tetracycline addition through western blot analysis.
Disease Status	Acute lymphoblastic leukemia	ICD-11: 2B33
Organ/Tissue/Cell Line	P493 cells (Human P493 B Lymphoma cells)	Lymph
Subcellular Location	Cytoplasm (Cytosol; Extracellular exosome)
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that tetracycline addition causes the decrease of PHGDH protein expression compared with control group in the human P493 B lymphoma cells.

References
1	cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res. 2015 Apr;25(4):429-44.

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