General Information of MET (ID: META00428)
Name Estrone sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulfate; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulfuric acid; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphate; 3-Hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphuric acid; Conestoral; Estrogenic substances; Estrone; Estrone 3-sulfate; Estrone 3-sulphate; Estrone hydrogen sulfate; Estrone hydrogen sulfuric acid; Estrone hydrogen sulphate; Estrone hydrogen sulphuric acid; Estrone sulfate sodium; Estrone sulfate, 14C-labeled; Estrone sulfate, 16-(14)C-labeled; Estrone sulfate, ammonium salt; Estrone sulfate, potassium salt; Estrone sulfate, sodium salt; Estrone sulfuric acid; Estrone sulphate; Estrone sulphate sodium; Estrone sulphuric acid; Estrone-3-sulfate; Estrone-3-sulphate; Evex; Oestrone sulphate; Potassium estrone sulfate; Premarin; Sodium estrone 3-monosulfate; Sodium estrone 3-monosulphate; Sodium estrone 3-sulfate; Sodium estrone 3-sulphate; Sodium estrone sulfate
Source Endogenous;Sterol lipids;Food;Drug
Structure Type   Sulfated steroids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Sulfated steroids
PubChem CID
3001028
HMDB ID
HMDB0001425
Formula
C18H22O5S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02538
DrugBank ID
DB04574
ChEBI ID
17474
FooDB ID
FDB021804
ChemSpider ID
2272513
METLIN ID
3556
Physicochemical Properties Molecular Weight 350.4 Topological Polar Surface Area 89
XlogP 2.5 Complexity 624
Heavy Atom Count 24 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Function
Estrone sulfate is a sulfated estrone derivative. Estrone sulfate acts as a long-lived reservoir that can be converted as needed to the more active estradiol (from estrone via 17 beta-hydroxysteroid dehydrogenase). Estrone Sulfate (E1S) is the most abundant circulating estrogen in non-pregnant women as well as normal men. Estrone is primarily synthesized from estrone sulfate. Estrone is an estrogenic hormone secreted by the ovaries and adipose tissues. Estrone is one of the three estrogens found in humans. The other two are estriol and estradiol. Estrone is the least prevalent of the three. Estradiol plays a critical role on reproductive and sexual functioning in women and it also affects other organs including the bones. Estriol is an estrogen that is prevalent primarily during pregnancy.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      ATP-binding cassette transporter (ABCT)
            ATP-binding cassette A8 (ABCA8) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of ABCA8
                      Induced Change Estrone sulfate concentration: increase (FC = 1.1)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of ABCA8 leads to the increase of estrone sulfate levels compared with control group.
            Multidrug resistance-associated 8 (MRP8) Click to Show/Hide the Full List of Regulating Pair(s):   4 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Inhibition (4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid) of ABCC11
                      Induced Change Estrone sulfate concentration: decrease (FC = 0.10)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of ABCC11 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Mutation (G180R) of ABCC11
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (G180R) of ABCC11 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (3) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Mutation (T546M) of ABCC11
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (T546M) of ABCC11 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (4) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of ABCC11
                      Induced Change Estrone sulfate concentration: increase (FC = 3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of ABCC11 leads to the increase of estrone sulfate levels compared with control group.
      Organic ion transporter (OIT)
            Solute carrier family 22 member 8 (SLC22A8) Click to Show/Hide the Full List of Regulating Pair(s):   9 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Bumetanide) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Cimetidine) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (3) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Furosemide) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (4) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Indomethacin) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (5) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Methotrexate) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (6) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Probenecid) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (7) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Steviol) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (8) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Unlabeled Estrone sulfate; Hoat3(ES)) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
               Regulating Pair (9) Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Inhibition (Unlabeled Para-aminohippurate (PAH)) of SLC22A8
                      Induced Change Estrone sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group.
      Organo anion transporter (OAT)
            Organic anion transporter D (SLCO3A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of SLCO3A1
                      Induced Change Estrone sulfate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO3A1 leads to the increase of estrone sulfate levels compared with control group.
            Organic anion transporter E (SLCO4A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of SLCO4A1
                      Induced Change Estrone sulfate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO4A1 leads to the increase of estrone sulfate levels compared with control group.
            Organic anion transporter F (SLCO1C1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [5]
                      Introduced Variation Overexpression of SLCO1C1
                      Induced Change Estrone sulfate concentration: increase (FC = 2)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO1C1 leads to the increase of estrone sulfate levels compared with control group.
            Solute carrier SLCO1B1 (OATP-C) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of SLCO1B1
                      Induced Change Estrone sulfate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO1B1 leads to the increase of estrone sulfate levels compared with control group.
            Solute carrier SLCO2B1 (OATPB) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Overexpression of SLCO2B1
                      Induced Change Estrone sulfate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLCO2B1 leads to the increase of estrone sulfate levels compared with control group.
      Sodium/anion cotransporter (SAC)
            Sodium-dependent phosphate transport 4 (SLC17A3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [6]
                      Introduced Variation Overexpression of SLC17A3
                      Induced Change Estrone sulfate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC17A3 leads to the increase of estrone sulfate levels compared with control group.
References
1 ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver. Mol Pharm. 2018 Feb 5;15(2):343-355.
2 Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant. Pharmacogenomics J. 2016 Apr;16(2):193-201.
3 Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8.
4 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
5 Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96.
6 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.

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