Details of Metabolite
Full List of Protein(s) Regulating This Metabolite | ||||||
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ATP-binding cassette transporter (ABCT) | ||||||
ATP-binding cassette A8 (ABCA8) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[1] | ||||
Introduced Variation | Overexpression of ABCA8 | |||||
Induced Change | Estrone sulfate concentration: increase (FC = 1.1) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of ABCA8 leads to the increase of estrone sulfate levels compared with control group. | |||||
Multidrug resistance-associated 8 (MRP8) | Click to Show/Hide the Full List of Regulating Pair(s): 4 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair (1) |
Experim Info
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[2] | ||||
Introduced Variation | Inhibition (4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid) of ABCC11 | |||||
Induced Change | Estrone sulfate concentration: decrease (FC = 0.10) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of ABCC11 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (2) |
Experim Info
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[2] | ||||
Introduced Variation | Mutation (G180R) of ABCC11 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (G180R) of ABCC11 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (3) |
Experim Info
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[2] | ||||
Introduced Variation | Mutation (T546M) of ABCC11 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that mutation (T546M) of ABCC11 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (4) |
Experim Info
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[2] | ||||
Introduced Variation | Overexpression of ABCC11 | |||||
Induced Change | Estrone sulfate concentration: increase (FC = 3) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of ABCC11 leads to the increase of estrone sulfate levels compared with control group. | |||||
Organic ion transporter (OIT) | ||||||
Solute carrier family 22 member 8 (SLC22A8) | Click to Show/Hide the Full List of Regulating Pair(s): 9 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair (1) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Bumetanide) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (2) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Cimetidine) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (3) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Furosemide) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (4) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Indomethacin) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (5) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Methotrexate) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (6) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Probenecid) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (7) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Steviol) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (8) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Unlabeled Estrone sulfate; Hoat3(ES)) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Regulating Pair (9) |
Experim Info
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[3] | ||||
Introduced Variation | Inhibition (Unlabeled Para-aminohippurate (PAH)) of SLC22A8 | |||||
Induced Change | Estrone sulfate concentration: decrease | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group. | |||||
Organo anion transporter (OAT) | ||||||
Organic anion transporter D (SLCO3A1) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLCO3A1 | |||||
Induced Change | Estrone sulfate concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLCO3A1 leads to the increase of estrone sulfate levels compared with control group. | |||||
Organic anion transporter E (SLCO4A1) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLCO4A1 | |||||
Induced Change | Estrone sulfate concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLCO4A1 leads to the increase of estrone sulfate levels compared with control group. | |||||
Organic anion transporter F (SLCO1C1) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[5] | ||||
Introduced Variation | Overexpression of SLCO1C1 | |||||
Induced Change | Estrone sulfate concentration: increase (FC = 2) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLCO1C1 leads to the increase of estrone sulfate levels compared with control group. | |||||
Solute carrier SLCO1B1 (OATP-C) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLCO1B1 | |||||
Induced Change | Estrone sulfate concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLCO1B1 leads to the increase of estrone sulfate levels compared with control group. | |||||
Solute carrier SLCO2B1 (OATPB) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Overexpression of SLCO2B1 | |||||
Induced Change | Estrone sulfate concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLCO2B1 leads to the increase of estrone sulfate levels compared with control group. | |||||
Sodium/anion cotransporter (SAC) | ||||||
Sodium-dependent phosphate transport 4 (SLC17A3) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[6] | ||||
Introduced Variation | Overexpression of SLC17A3 | |||||
Induced Change | Estrone sulfate concentration: increase | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of SLC17A3 leads to the increase of estrone sulfate levels compared with control group. | |||||
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