| Regulating Pair |
| Introduced Variation |
Inhibition (Probenecid) of SLC22A8 |
Protein Info
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| Induced Change |
Estrone sulfate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of estrone sulfate concentration after SLC22A8 inhibition through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Xenopus laevis oocytes |
N.A. |
| Subcellular Location |
Membrane (Basolateral cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of SLC22A8 leads to the decrease of estrone sulfate levels compared with control group in xenopus laevis oocytes. |
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| References |
| 1 |
Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8.
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