Details of Metabolite

General Information of MET (ID: META01137)
Name Sodium oxamate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
sodium oxamate; 565-73-1; Oxamic acid sodium salt; Sodium 2-amino-2-oxoacetate; Oxamic acid, sodium salt; Acetic acid, aminooxo-, monosodium salt; Oxamate (sodium); Aminooxoacetic acid sodium salt; MFCD00044553; Acetic acid, 2-amino-2-oxo-, sodium salt (1:1); Oxalic acid monoamide sodium salt; Oxamic acid sodium; EINECS 209-290-5; C2H2NNaO3; Lopac-O-2751; SCHEMBL2370295; CHEMBL1256289; DTXSID1060342; 3-n-phthaloylglyaminomethylaniline; HMS3262H08; Tox21_500913; BDBM50144744; KM0009; AKOS024462579; CCG-222217; LP00913; NCGC00016183-01; NCGC00016183-02; NCGC00094224-01; NCGC00261598-01; DB-052941; EU-0100913; FT-0632400; Z3402; O 2751
Source Food additives
Structure Type Organic acids
PubChem CID
5202
Formula
C2H2NNaO3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=5202"></iframe>
3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 111.03 Topological Polar Surface Area 83.2
XlogP N.A. Complexity 90.9
Heavy Atom Count 7 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      Interferon (IF)
            Interferon-beta (IFNB1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Sodium oxamate addition (2 hours)
                      Induced Change IFNB1 protein abundance levels: increase (FC = 2)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that sodium oxamate addition causes the increase of IFNB1 mRNA levels compared with control group.
      Interleukin (IL)
            Interleukin-6 (IL6) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Sodium oxamate addition (4 hours)
                      Induced Change IL6 mRNA levels: increase (FC = 3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that sodium oxamate addition causes the increase of IL6 mRNA levels compared with control group.
      Transcription factor (TF)
            Interferon regulatory factor 3 (IRF3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Sodium oxamate addition (12 hours)
                      Induced Change IRF3 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that sodium oxamate addition causes the increase of IRF3 protein phosphorylation compared with control group.
      Transferases (EC 2)
            NF-kappa-B-activating kinase (TBK1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Sodium oxamate addition (3 hours)
                      Induced Change TBK1 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute lymphoblastic leukemia [ICD-11: 2B33]
                      Details It is reported that sodium oxamate addition causes the increase of TBK1 protein phosphorylation compared with control group.
References
1 Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15.

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