Details of Experiment

Regulating Pair
Introduced Variation	Sodium oxamate addition (12 hours)	Metabo Info
Induced Change	IRF3 protein phosphorylation levels: increase	Protein Info
Summary	Introduced Variation Induced Change

Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair			[1]
Method	Quantifying the variation of IRF3 protein phosphorylation abundances after sodium oxamate addition through western blot analysis.
Disease Status	Acute lymphoblastic leukemia	ICD-11: 2B33
Organ/Tissue/Cell Line	Hep3B cells (Human hepatoma cells)	Liver
Subcellular Location	Cytoplasm; Nucleus; Mitochondrion
Tested Species	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Details	It is reported that sodium oxamate addition causes the increase of IRF3 protein phosphorylation compared with control group in the Hep3B cells.

References
1	Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019 Jun 27;178(1):176-189.e15.

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