Details of Protein

General Information of Protein (ID: PRT00661)
Name G-protein coupled receptor 183 (GPR183)
Synonyms   Click to Show/Hide Synonyms of This Protein
Epstein-Barr virus-induced G-protein coupled receptor 2; EBI2; EBV-induced G-protein coupled receptor 2; hEBI2; GPR183; EBI2
Gene Name GPR183 Gene ID
1880
UniProt ID
P32249
Family GPCR rhodopsin (GPCR-1)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNR
KKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVN
FMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERIT
CMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNK
KALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFN
CCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNG
K
Function G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes. Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses. Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5. Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand. Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand. Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels. Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages. Promotes osteoclast precursor migration to bone surfaces. Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Lipids and lipid-like molecules
            7-Alpha,27-Dihydroxycholesterol Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 7-Alpha,27-Dihydroxycholesterol addition (48 hours)
                      Induced Change GPR183 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Systemic inflammatory response syndrome [ICD-11: 1H0Z]
                      Details It is reported that 7-alpha,27-dihydroxycholesterol addition causes the increase of GPR183 protein activity compared with control group.
            7-Alpha-Hydroxycholesterol Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 7-Alpha-Hydroxycholesterol addition (48 hours)
                      Induced Change GPR183 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Systemic inflammatory response syndrome [ICD-11: 1H0Z]
                      Details It is reported that 7-alpha-hydroxycholesterol addition causes the increase of GPR183 protein activity compared with control group.
            7-Beta, 25-Dihydroxycholesterol Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 7-Beta, 25-Dihydroxycholesterol addition (48 hours)
                      Induced Change GPR183 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Systemic inflammatory response syndrome [ICD-11: 1H0Z]
                      Details It is reported that 7-beta, 25-Dihydroxycholesterol addition causes the increase of GPR183 protein activity compared with control group.
References
1 Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

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