Details of Metabolite

General Information of MET (ID: META00975)
Name 7-Beta, 25-Dihydroxycholesterol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
7beta, 25-dihydroxycholesterol; CHEMBL3311219; (3S,7R,8S,9S,10R,13R,14S,17R)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; 7beta,25-dihydroxycholesterol; GTPL4355; SCHEMBL2485860; 7.beta.,25-Dihydroxycholesterol; BDBM50045543; Q27074029; (3.beta.,7.beta.)-7,25-Dihydroxycholest-5-en-3-ol; (3S,7R,8S,9S,10R,13R,14S,17R)-17-[(1R)-5-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
Source Endogenous;Yeast Metabolite;Sterol lipids;Food;Toxins/Pollutant;Cosmetic;TCM Ingredients;Microbial
Structure Type   Retinoids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Prenol lipids
Retinoids
PubChem CID
473142
Formula
C27H46O3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=473142"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 418.7 Topological Polar Surface Area 60.7
XlogP 5.7 Complexity 669
Heavy Atom Count 30 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            G-protein coupled receptor 183 (GPR183) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 7-Beta, 25-Dihydroxycholesterol addition (48 hours)
                      Induced Change GPR183 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Systemic inflammatory response syndrome [ICD-11: 1H0Z]
                      Details It is reported that 7-beta, 25-Dihydroxycholesterol addition causes the increase of GPR183 protein activity compared with control group.
References
1 Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.

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