| Regulating Pair |
| Introduced Variation |
7-Alpha,27-Dihydroxycholesterol addition (48 hours) |
Metabo Info
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| Induced Change |
GPR183 protein activity levels: increase |
Protein Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the variation of GPR183 protein activity abundances after 7beta-27-hydroxycholesterol addition through GTPS binding assay analysis. |
| Disease Status |
Systemic inflammatory response syndrome |
ICD-11: 1H0Z |
| Organ/Tissue/Cell Line |
CHO-k1 cells (Chinese hamster ovary cells) |
Ovary |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that 7-alpha,27-dihydroxycholesterol addition causes the increase of GPR183 protein activity compared with control group in the CHO-k1 cells. |
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| References |
| 1 |
Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.
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