Details of Metabolite

General Information of MET (ID: META00965)
Name 2-Oleoyl-LPA
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Oleoyl-LPA; 2Acyl-LPA; 2-acyl-1LPA; 2-oleoyl-glycero-3-phosphate; Lysophosphatidic acid(0:0/18:1); LPA(0:0/18:1n9); Lysophosphatidic acid(0:0/18:1n9); 2-(9Z-octadecenoyl)-phosphatidic acid; LPA(0:0/18:1); GTPL2936; LysoPA(0:0/18:1(9Z)); 2-monooleoyl-rac-glycerol 3-phosphate; LPA(0:0/18:1w9); Lysophosphatidic acid(0:0/18:1w9); Q27072655; (1-hydroxy-3-phosphonooxypropan-2-yl) (Z)-octadec-9-enoate; {3-hydroxy-2-[(9Z)-octadec-9-enoyloxy]propoxy}phosphonic acid
Source Endogenous;Sterol lipids;Food
Structure Type   Glycerophosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphates
PubChem CID
56947016
Formula
C21H41O7P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 436.5 Topological Polar Surface Area 113
XlogP 5.2 Complexity 462
Heavy Atom Count 29 Rotatable Bond Count 21
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            Kynurenic acid receptor (GPR35) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Oleoyl-LPA addition (2.7810^-4 hours)
                      Induced Change GPR35 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Stomach cancer [ICD-11: 2B72]
                      Details It is reported that 2-oleoyl-LPA addition causes the increase of GPR35 protein activity compared with control group.
      Hydrolases (EC 3)
            Transforming protein RhoA (RHOA) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Oleoyl-LPA addition (0.25 hour)
                      Induced Change RHOA protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Stomach cancer [ICD-11: 2B72]
                      Details It is reported that 2-oleoyl-LPA addition causes the increase of RHOA protein phosphorylation compared with control group.
      Transferases (EC 2)
            Signal-regulated kinase 1 (ERK1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Oleoyl-LPA addition (0.08 hours)
                      Induced Change MAPK3 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Stomach cancer [ICD-11: 2B72]
                      Details It is reported that 2-oleoyl-LPA addition causes the increase of MAPK3 protein phosphorylation compared with control group.
            Signal-regulated kinase 2 (ERK2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation 2-Oleoyl-LPA addition (0.08 hours)
                      Induced Change MAPK1 protein phosphorylation levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Stomach cancer [ICD-11: 2B72]
                      Details It is reported that 2-oleoyl-LPA addition causes the increase of MAPK1 protein phosphorylation compared with control group.
References
1 GPR35 is a novel lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2010 Apr 30;395(2):232-7.

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