Details of Metabolite

General Information of MET (ID: META00687)
Name 4-Phenylpyridine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Methyl-4-phenylpyridinium', 4-Aza-1,1'-biphenyl, 'Cyperquat; 4-Phenyl-pyridine; N-Methyl-4-phenylpyridine; Phenyl-pyridine; p-Phenylpyridine
Source Food;TCM Ingredients
Structure Type   Phenylpyridines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Phenylpyridines
PubChem CID
13651
HMDB ID
HMDB0033123
Formula
C11H9N
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C11310
FooDB ID
FDB011123
ChemSpider ID
13062
Physicochemical Properties Molecular Weight 155.2 Topological Polar Surface Area 12.9
XlogP 2.6 Complexity 121
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 1
Function
4-Phenylpyridine is found in herbs and spices. 4-Phenylpyridine occurs in tea and peppermint.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Organic ion transporter (OIT)
            Organic cation transporter 2 (OCT2) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexperisson of SLC22A2
                      Induced Change 4-Phenylpyridine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Basal cell carcinoma [ICD-11: 2C32]
                      Details It is reported that co-overexperisson of SLC22A2 and IRIP leads to the decrease of 4-phenylpyridine levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC22A2
                      Induced Change 4-Phenylpyridine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC22A2 leads to the increase of 4-phenylpyridine levels compared with control group.
      RNA-binding protein (RBP)
            Dopamine receptor-interacting 3 (DRIP3) Click to Show/Hide the Full List of Regulating Pair(s):   4 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (T87L; K110I) of YRDC
                      Induced Change 4-Phenylpyridine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Basal cell carcinoma [ICD-11: 2C32]
                      Details It is reported that mutation (T87L and K110I) of YRDC leads to the increase of 4-phenylpyridine levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexperisson of YRDC
                      Induced Change 4-Phenylpyridine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Basal cell carcinoma [ICD-11: 2C32]
                      Details It is reported that co-overexperisson of SLC22A2 and IRIP leads to the decrease of 4-phenylpyridine levels compared with control group.
               Regulating Pair (3) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of YRDC
                      Induced Change 4-Phenylpyridine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Basal cell carcinoma [ICD-11: 2C32]
                      Details It is reported that knockdown of YRDC leads to the increase of 4-phenylpyridine levels compared with control group.
               Regulating Pair (4) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of YRDC
                      Induced Change 4-Phenylpyridine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Basal cell carcinoma [ICD-11: 2C32]
                      Details It is reported that overexpression of YRDC leads to the decrease of 4-phenylpyridine levels compared with control group.
References
1 IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Mol Cell Biol. 2005 Aug;25(15):6496-508.
2 Transport of asymmetric dimethylarginine (ADMA) by cationic amino acid transporter 2 (CAT2), organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1). Amino Acids. 2013 Oct;45(4):989-1002.

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