| Regulating Pair |
| Introduced Variation |
Mutation (T87L; K110I) of YRDC |
Protein Info
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| Induced Change |
4-Phenylpyridine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of 4-phenylpyridine concentration after YRDC mutation (T87L; K110I) through kit detection. |
| Disease Status |
Basal cell carcinoma |
ICD-11: 2C32 |
| Organ/Tissue/Cell Line |
HeLa cells (Human cervical cancer cells) |
Cervix |
| Subcellular Location |
Mitochondrion; Membrane |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (T87L and K110I) of YRDC leads to the increase of 4-phenylpyridine levels compared with control group in HeLa cells. |
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| References |
| 1 |
IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Mol Cell Biol. 2005 Aug;25(15):6496-508.
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