Details of Metabolite

General Information of MET (ID: META00680)
Name Methyl beta-D-glucopyranoside
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-O-Methyl-beta-D-glucopyranoside; 1-O-Methylglucose; Beta-Methyl-D-glucoside; D-Glucoside, methyl; Methyl D-glucopyranoside; Methyl D-glucoside; Methyl beta-D-glucoside; Methyl glucose; Methyl hexopyranoside; Methyl-D-glucoside; Methylglucoside; Methylglucoside, (beta-D)-isomer; beta-D-Methylglucopyranoside; beta-Methylglucoside
Source Endogenous;Food;Drug
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
445238
HMDB ID
HMDB0029965
Formula
C7H14O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB01642
ChEBI ID
320055
Physicochemical Properties Molecular Weight 194.18 Topological Polar Surface Area 99.4
XlogP -2.2 Complexity 163
Heavy Atom Count 13 Rotatable Bond Count 2
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Methyl beta-D-glucopyranoside is found in cereals and cereal products. Methyl beta-D-glucopyranoside is present in Medicago sativa (alfalfa
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sodium:solute symporter (SSS)
            Sodium/glucose cotransporter 2 (SGLT2) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Inhibition (Phlorizin) of SLC5A2
                      Induced Change Methyl beta-D-glucopyranoside concentration: decrease (FC = 20)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that inhibition of SLC5A2 leads to the decrease of methyl beta-D-glucopyranoside levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC5A2
                      Induced Change Methyl beta-D-glucopyranoside concentration: increase (FC = 3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Type 2 diabetes mellitus [ICD-11: 5A11]
                      Details It is reported that overexpression of SLC5A2 leads to the increase of methyl beta-D-glucopyranoside levels compared with control group.
      Sugar transporter (ST)
            HepG2 glucose transporter (SLC2A1) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Mutation (Gly286Asp) of SLC2A1
                      Induced Change Methyl beta-D-glucopyranoside concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary haemolytic anaemia [ICD-11: 3A10]
                      Details It is reported that mutation (Gly286Asp) of SLC2A1 leads to the decrease of methyl beta-D-glucopyranoside levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Mutation (S290A) of SLC2A1
                      Induced Change Methyl beta-D-glucopyranoside concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary haemolytic anaemia [ICD-11: 3A10]
                      Details It is reported that mutation (S290A) of SLC2A1 leads to the decrease of methyl beta-D-glucopyranoside levels compared with control group.
References
1 Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan;300(1):C14-21.
2 Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome. Blood. 2011 Nov 10;118(19):5267-77.

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