| Regulating Pair |
| Introduced Variation |
Inhibition (Phlorizin) of SLC5A2 |
Protein Info
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| Induced Change |
Methyl beta-D-glucopyranoside concentration: decrease (FC = 20) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of methyl beta-D-glucopyranoside concentration after SLC5A2 inhibition through 14C-labeled amino acids kit detection. |
| Disease Status |
Type 2 diabetes mellitus |
ICD-11: 5A11 |
| Organ/Tissue/Cell Line |
HEK293 cells (Human embryonic kidney cells) |
Kidney |
| Subcellular Location |
Membrane |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that inhibition of SLC5A2 leads to the decrease of methyl beta-D-glucopyranoside levels compared with control group in HEK293 cells. |
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| References |
| 1 |
Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol. 2011 Jan;300(1):C14-21.
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