Details of Metabolite

General Information of MET (ID: META00473)
Name N-Methyl-a-aminoisobutyric acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-(Methylamino)isobutyrate; 2-(Methylamino)isobutyric acid; AMAIB; N-(Methylamino)isobutyric acid; N-Methyl alpha-aminoisobutyric acid; N-Methyl-a-aminoisobutyrate; N-Methyl-alpha-aminoisobutyrate; N-Methyl-alpha-aminoisobutyric acid; N-Methylaminoisobutyrate; N-Methylaminoisobutyric acid; a-(Methylamino)isobutyrate; alpha-(Methylamino)isobutyrate; alpha-Methylaminoisobutyrate
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
6951124
HMDB ID
HMDB0002141
Formula
C5H11NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB08832
ChEBI ID
134261
FooDB ID
FDB022865
ChemSpider ID
68242
METLIN ID
6508
Physicochemical Properties Molecular Weight 117.15 Topological Polar Surface Area 56.7
XlogP -1.6 Complexity 93.1
Heavy Atom Count 8 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
N-Methyl-a-aminoisobutyric acid is a metabolite that is actively incorporated into the cell by the actions of Interleukin 1-beta and Interleukin 6 via sodium dependent transport systems.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Amino acid/auxin permease (AAAP)
            Sodium-coupled neutral amino transporter 8 (SLC38A8) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC38A8
                      Induced Change N-Methyl-a-aminoisobutyric acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC38A8 leads to the increase of N-methyl-a-aminoisobutyric acid levels compared with control group.
            Solute carrier family 38 member 1 (SLC38A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC38A1
                      Induced Change N-Methyl-a-aminoisobutyric acid concentration: increase (FC = 8)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC38A1 leads to the increase of N-methyl-a-aminoisobutyric acid levels compared with control group.
            Solute carrier family 38 member 2 (SLC38A2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC38A2
                      Induced Change N-Methyl-a-aminoisobutyric acid concentration: increase (FC = 11)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC38A2 leads to the increase of N-methyl-a-aminoisobutyric acid levels compared with control group.
            Solute carrier family 38 member 4 (SLC38A4) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC38A4
                      Induced Change N-Methyl-a-aminoisobutyric acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC38A4 leads to the increase of N-methyl-a-aminoisobutyric acid levels compared with control group.
References
1 Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. J Mol Biol. 2015 Mar 27;427(6 Pt B):1495-1512.
2 Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):10-7.

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