| Regulating Pair |
| Introduced Variation |
Overexpression of SLC38A2 |
Protein Info
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| Induced Change |
N-Methyl-a-aminoisobutyric acid concentration: increase (FC = 11) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of N-methyl-a-aminoisobutyric acid concentration after SLC38A2 overexpression through [3H]labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
HRPE cells (Human retinal pigment epithelial cells) |
Retina |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of SLC38A2 leads to the increase of N-methyl-a-aminoisobutyric acid levels compared with control group in HRPE cells. |
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| References |
| 1 |
Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. Biochim Biophys Acta. 2001 Feb 9;1510(1-2):10-7.
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