Details of Metabolite

General Information of MET (ID: META00432)
Name Sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Acide sulfurique; Acide sulphurique; Acido sulfurico; Acido sulphurico; Acidum sulfuricum; Acidum sulphuricum; H2SO4; Schwefelsaeureloesungen; Sulfate; Sulfuric acid; Sulphate; Sulphuric acid; [S(OH)2O2]; [SO2(OH)2]
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Agricultural Chemicals;Toxins/Pollutant;Cosmetic;Food additives;TCM Ingredients;Microbial
Structure Type   Non-metal sulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Homogeneous non-metal compounds
Non-metal oxoanionic compounds
Non-metal sulfates
PubChem CID
1117
HMDB ID
HMDB0001448
Formula
H2O4S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00059
DrugBank ID
DB11309
ChEBI ID
26836
FooDB ID
FDB013392
ChemSpider ID
1086
METLIN ID
3233
Physicochemical Properties Molecular Weight 96.07 Topological Polar Surface Area 88.6
XlogP -1.5 Complexity 62.2
Heavy Atom Count 5 Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 4
Function
The sulfate ion is a polyatomic anion with the empirical formula SO42- and a molecular mass of 96.06 daltons; it consists of one central sulfur atom surrounded by four equivalent oxygen atoms in a tetrahedral arrangement. The sulfate ion carries a negative two charge and is the conjugate base of the hydrogen sulfate ion, HSO4-, which is the conjugate base of H2SO4, sulfuric acid. In inorganic chemistry, a sulfate (IUPAC-recommended spelling; also sulphate in British English) is a salt of sulfuric acid. Sulfate aerosols can act as cloud condensation nuclei and this leads to greater numbers of smaller droplets of water. Lots of smaller droplets can diffuse light more efficiently than just a few larger droplets.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Sulfate concentration: decrease (FC = 0.83)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of sulfate levels compared with control group.
      Sulfate permease (SULP)
            Sodium-independent sulfate anion transporter (SLC26A11) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Inhibition (4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)) of SLC26A11
                      Induced Change Sulfate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that inhibition of SLC26A11 leads to the decrease of sulfate levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of SLC26A11
                      Induced Change Sulfate concentration: increase (FC = 3)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC26A11 leads to the increase of sulfate levels compared with control group.
            Solute carrier family 26 member 1 (SLC26A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of SLC26A1
                      Induced Change Sulfate concentration: increase (FC = 40)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC26A1 leads to the increase of sulfate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules. FASEB J. 2003 May;17(8):890-2.
3 Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1). DNA Cell Biol. 2003 Feb;22(2):107-17.

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