Details of Metabolite

General Information of MET (ID: META00356)
Name DL-2-Aminooctanoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(+-)-2-Aminooctanoate; (+-)-2-Aminooctanoic acid; (+/-)-2-amino-octanoate; (+/-)-2-amino-octanoic acid; (+/-)-2-aminooctanoate; (+/-)-2-aminooctanoic acid; 2-Amino-DL-caprylate; 2-Amino-DL-caprylic acid; 2-Amino-DL-octanoate; 2-Amino-DL-octanoic acid; 2-Aminocaprylate; 2-Aminocaprylic acid; 2-Aminooctanoate; 2-Aminooctanoic acid; D,L-2-Aminooctanoate; D,L-2-Aminooctanoic acid; DL-2-Amino-octanoate; DL-2-Aminocaprylate; DL-2-Aminocaprylic acid; DL-2-Aminooctanoate; DL-2-Aminooctanoic acid; DL-a-Amino-N-caprylate; DL-a-Amino-N-caprylic acid; DL-a-Aminocaprylate; DL-a-Aminocaprylic acid; DL-alpha-Amino-N-caprylic acid; DL-alpha-Aminocaprylic acid; NSC 20147; a-Aminocaprylate; a-Aminocaprylic acid; a-Aminooctanoate; a-Aminooctanoic acid; alpha-Aminocaprylic acid; alpha-Aminooctanoic acid
Source Endogenous;Fatty acyls;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
69522
HMDB ID
HMDB0000991
Formula
C8H17NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
75145
FooDB ID
FDB022354
ChemSpider ID
62727
METLIN ID
5923
Physicochemical Properties Molecular Weight 159.23 Topological Polar Surface Area 63.3
XlogP -0.5 Complexity 115
Heavy Atom Count 11 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
alpha-Aminooctanoic acid is an amino compound found occasionally in human urine. alpha-Aminooctanoic acid has been found in one case in the milk of a lactating mother at the 144th day of lactation. (Science and Culture (1960), 26 186-7.).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change DL-2-Aminooctanoic acid concentration: increase (FC = 1.74)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of DL-2-Aminooctanoic acid levels compared with control group.
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change DL-2-Aminooctanoic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of DL-2-Aminooctanoic acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
2 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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