| Regulating Pair |
| Introduced Variation |
Mutation (-265T >C(rs5082)) of APOA2 |
Protein Info
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| Induced Change |
DL-2-Aminooctanoic acid concentration: increase (FC = 1.74) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of DL-2-aminooctanoic acid concentration after APOA2 mutation (-265T >C(rs5082)) through ultrahigh-performance liquid chromatography-tandem mass spectroscopy based metabolomics. |
| Disease Status |
Obesity |
ICD-11: 5B81 |
| Organ/Tissue/Cell Line |
N.A. |
Plasma |
| Subcellular Location |
Secreted |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of DL-2-Aminooctanoic acid levels compared with control group. |
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| References |
| 1 |
Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.
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