Details of Metabolite

General Information of MET (ID: META00354)
Name Hypotaurine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Amino-ethanesulfinate; 2-Amino-ethanesulfinic acid; 2-Aminoethanesulfinate; 2-Aminoethanesulfinic acid; 2-Aminoethanesulphinate; 2-Aminoethanesulphinic acid; 2-Aminoethylsulfinate; 2-Aminoethylsulfinic acid; Cystaminesulfinate; Cystaminesulfinic acid
Source Endogenous;Escherichia Coli Metabolite;Food;Cosmetic;Microbial
Structure Type   Sulfinic acids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Sulfinic acids and derivatives
Sulfinic acids
PubChem CID
107812
HMDB ID
HMDB0000965
Formula
C2H7NO2S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00519
ChEBI ID
16668
FooDB ID
FDB022342
ChemSpider ID
96959
METLIN ID
281
Physicochemical Properties Molecular Weight 109.15 Topological Polar Surface Area 82.5
XlogP -1.5 Complexity 55.5
Heavy Atom Count 6 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
Hypotaurine is a product of enzyme cysteamine dioxygenase [EC 1.13.11.19] in taurine and hypotaurine metabolism pathway (KEGG). It may function as an antioxidant and a protective agent under physiological conditions.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Hypotaurine concentration: increase (FC = 1.99 - 2.38)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the increase of hypotaurine levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Hypotaurine concentration: decrease (Log2 FC=0.7)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of hypotaurine levels compared with control group.
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change Hypotaurine concentration: decrease (FC = 0.60)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the decrease of hypotaurine levels compared with control group.
      Transmembrane protein (TMEM)
            Extracellular matrix receptor III (CD44) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [4]
                      Introduced Variation Knockdown (shRNA) of CD44
                      Induced Change Hypotaurine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockdown of CD44 leads to the increase of hypotaurine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.
3 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
4 Gold-nanofve surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nat Commun. 2018 Apr 19;9(1):1561.

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