| Regulating Pair |
| Introduced Variation |
Knockdown (shRNA) of CD44 |
Protein Info
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| Induced Change |
Hypotaurine concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of hypotaurine concentration after CD44 knockdown through CE-MS based metabolomics. |
| Disease Status |
Colon cancer |
ICD-11: 2B90 |
| Organ/Tissue/Cell Line |
HCT116 cells (Human colon carcinoma cells) |
Colon |
| Subcellular Location |
Membrane (Cell membrane); Cell projection (Microvillus) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of CD44 leads to the increase of hypotaurine levels compared with control group in HCT116 cells. |
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| References |
| 1 |
Gold-nanofve surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nat Commun. 2018 Apr 19;9(1):1561.
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