Details of Protein

General Information of Protein (ID: PRT01601)
Name N-acylneuraminate-9-phosphatase (NANP)
Synonyms   Click to Show/Hide Synonyms of This Protein
Haloacid dehalogenase-like hydrolase domain-containing protein 4; Neu5Ac-9-Pase; NANP; C20orf147; HDHD4
Gene Name NANP Gene ID
140838
UniProt ID
Q8TBE9
Family Hydrolases (EC 3)
EC Number   EC: 3.1.3.29  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.29
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MGLSRVRAVFFDLDNTLIDTAGASRRGMLEVIKLLQSKYHYKEEAEIICDKVQVKLSKEC
FHPYNTCITDLRTSHWEEAIQETKGGAANRKLAEECYFLWKSTRLQHMTLAEDVKAMLTE
LRKEVRLLLLTNGDRQTQREKIEACACQSYFDAVVVGGEQREEKPAPSIFYYCCNLLGVQ
PGDCVMVGDTLETDIQGGLNAGLKATVWINKNGIVPLKSSPVPHYMVSSVLELPALLQSI
DCKVSMST
Structure
2W4M ; 4KNV ; 4KNW
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Nucleosides, nucleotides, and analogues
            CMP-N-Acetylneuraminate Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of NANP
                      Induced Change CMP-N-Acetylneuraminate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Carbohydrate metabolism disorders [ICD-11: 5C51]
                      Details It is reported that knockout of NANP leads to the decrease of CMP-N-acetylneuraminate levels compared with control group.
      Organic oxygen compounds
            N-Acetylneuraminic acid Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of NANP
                      Induced Change N-Acetylneuraminic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Carbohydrate metabolism disorders [ICD-11: 5C51]
                      Details It is reported that knockout of NANP leads to the decrease of N-acetylneuraminic acid levels compared with control group.
References
1 Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis. Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1471-1479.

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