| Regulating Pair |
| Introduced Variation |
Knockout of NANP |
Protein Info
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| Induced Change |
N-Acetylneuraminic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of N-acetylneuraminic acid concentration after NANP knockout through LC-MS based metabolomics. |
| Disease Status |
Carbohydrate metabolism disorders |
ICD-11: 5C51 |
| Organ/Tissue/Cell Line |
CHO cells (Chinese Hamster Ovary cells) |
Ovary |
| Subcellular Location |
Cytoplasm (Cytosol) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockout of NANP leads to the decrease of N-acetylneuraminic acid levels compared with control group in CHO cells. |
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| References |
| 1 |
Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis. Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1471-1479.
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