Details of Experiment

Regulating Pair
       Introduced Variation Knockout of NANP Protein Info
       Induced Change CMP-N-Acetylneuraminate concentration: decrease Metabo Info
       Summary Introduced Variation         Induced Change 
Full List of Experiment(s) Validating This Regulating Pair
Details of Experiment for Validating This Pair [1]
       Method Quantifying the change of cytidine 5'-monophosphate-N-acetylneuraminic acid concentration after NANP knockout through LC-MS based metabolomics.
       Disease Status Carbohydrate metabolism disorders ICD-11: 5C51
       Organ/Tissue/Cell Line HAP1 cells (Human haploid cells) Ovary
CHO cells (Chinese Hamster Ovary cells) Ovary
       Subcellular Location Cytoplasm (Cytosol)
       Tested Species   Species: Homo sapiens  (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
       Details It is reported that knockout of NANP leads to the decrease of CMP-N-acetylneuraminate levels compared with control group in HAP1 cells and CHO cells.
References
1 Activity of N-acylneuraminate-9-phosphatase (NANP) is not essential for de novo sialic acid biosynthesis. Biochim Biophys Acta Gen Subj. 2019 Oct;1863(10):1471-1479.

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