Details of Protein

General Information of Protein (ID: PRT01581)
Name Renal carcinoma antigen NY-REN-56 (PFKFB3)
Synonyms   Click to Show/Hide Synonyms of This Protein
6PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Renal carcinoma antigen NY-REN-56; iPFK-2; PFKFB3
Gene Name PFKFB3 Gene ID
5209
UniProt ID
Q16875
Family Transferases (EC 2)
EC Number   EC: 2.7.1.105  (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.105
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
Structure
2AXN ; 2DWO ; 2DWP ; 2I1V ; 3QPU ; 3QPV ; 3QPW ; 4D4J ; 4D4K ; 4D4L ; 4D4M ; 4MA4 ; 5AJV ; 5AJW ; 5AJX ; 5AJY ; 5AJZ ; 5AK0 ; 6ETJ ; 6HVH ; 6HVI ; 6HVJ ; 6IBX ; 6IBY ; 6IBZ ; 6IC0
Function Synthesis and degradation of fructose 2,6-bisphosphate.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organic oxygen compounds
            D-Fructose 2,6-bisphosphate Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of PFKFB3
                      Induced Change D-Fructose 2,6-bisphosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of PFKFB3 leads to the increase of D-fructose 2,6-bisphosphate levels compared with control group.
References
1 Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain. Biochem Biophys Res Commun. 2008 Jan 11;365(2):291-7.

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