| Regulating Pair |
| Introduced Variation |
Overexpression of PFKFB3 |
Protein Info
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| Induced Change |
D-Fructose 2,6-bisphosphate concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of D-fructose 2,6-bisphosphate concentration after PFKFB3 overexpression through kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Cytoplasm (Cytosol); Nucleus (Nucleoplasm) |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that overexpression of PFKFB3 leads to the increase of D-fructose 2,6-bisphosphate levels compared with control group. |
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| References |
| 1 |
Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain. Biochem Biophys Res Commun. 2008 Jan 11;365(2):291-7.
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