Details of Protein

General Information of Protein (ID: PRT01155)
Name ATP-binding cassette A5 (ABCA5)
Synonyms   Click to Show/Hide Synonyms of This Protein
Cholesterol transporter ABCA5; Abca5; Kiaa1888
Gene Name Abca5 Gene ID
217265
UniProt ID
Q8K448
Family Translocases (EC 7)
EC Number   EC: 7.6.2.-  (Click to Show/Hide the Complete EC Tree)
Translocase
Other compounds translocase
Other nucleoside triphosphate translocase
EC: 7.6.2.-
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MATAIRDVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILVSMMHPNKKYEE
VSDIELSPMDKFSLSNVILGYTPVTNITSSIMQRVSTDHLPKVIVTEEYANEKELVAASL
SKSSNFVGVVFKDTMSYELRFFPEMIPVSSIYMNSREGCSKTCDAAQYWSLGFTVLQASI
DAAIIQLKTNVSVWSELESTKAVIMGEAAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHI
VAEKEKKLKEFLKIMGLHDTAFWLSWVLLYASLIFLMSLLMAVIATASSLFPQSSSIVIF
LLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLIESFPRSLVWLFS
PLCQCAFLIGIAQVMHLEDFNEGALFSNLTEGPYPLIITIIMLALDSVFYVLLAVYLDQV
IPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRI
SGIQKSYRKKTENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQSDINFDVLTVEENLSILASIKGIPANNIIQEVQKVLL
DLDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYR
KANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCAT
ESLSSLVRQHIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTT
LEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASSVSTMSLW
KQQVSTIAKFHFLSLKRESKSVRAVLLLLLIFFAVQIFMFFLHHSFKNAVVPIKLVPDLY
FLKPGDKPHKYKTSLLLQNSTDSDINGLIEFFAHQNIMVAMFNDSDYVSAAPHSAALNVV
RSEKDYVFSAVFNSTMVYCLPVMMNIISNYYLYHLNVTEAIQTWSTPFIQEITDIVFKIE
LYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVV
LILMLGSLFAFHHGLYFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFI
YSVTALACVAITETTFFLQYAVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNMPKNENT
YNPWDRLLVAVIMPYLQCILWIFLLQHYEKIHGGRSIRKDPFFRALSQKAKNKKFPEPPI
NEDEDEDVKAERLKVKELMGCQCCEEKPAIMVCNLHKEYDDKKDFLHSRKTTKVATKYIS
FCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDESIKCMGYCP
QTNPLWPDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRK
LCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVC
DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQYIFPNASRQ
ESFSSILAFKIPKEDVQSLSQSFAKLEEAKRTFAIEEYSFSQATLEQVFVELTKEQEEED
NSCGTLASTLWWERTQEDRVVF
Function Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Lipids and lipid-like molecules
            Cholesterol Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Abca5
                      Induced Change Cholesterol concentration: increase (FC = 1.21)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Abca5 leads to the increase of cholesterol levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Abca5
                      Induced Change Cholesterol concentration: decrease (FC = 0.71)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Abca5 leads to the decrease of cholesterol levels compared with control group.
            TG(8:0/8:0/8:0) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Abca5
                      Induced Change TG(8:0/8:0/8:0) concentration: increase (FC = 2.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Abca5 leads to the increase of TG(8:0/8:0/8:0) levels compared with control group.
References
1 Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun. 2010 May 7;395(3):387-94.

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