| Regulating Pair |
| Introduced Variation |
Knockout of Abca5 |
Protein Info
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| Induced Change |
Cholesterol concentration: decrease (FC = 0.71) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of cholesterol concentration after Abca5 knockout through 3H-labeled amino acids kit detection. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Macrophages |
Bone marrow |
| Subcellular Location |
Golgi apparatus (Golgi apparatus membrane); Lysosome (Lysosome membrane); Endosome (Late endosome membrane); Membrane (Cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Abca5 leads to the decrease of cholesterol levels compared with control group in Macrophages. |
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| References |
| 1 |
Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun. 2010 May 7;395(3):387-94.
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