Details of Metabolite

General Information of MET (ID: META00602)
Name TG(8:0/8:0/8:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,2,3-Propanetriol trioctanoate; 1,2,3-Propanetriol trioctanoic acid; 1,2,3-Trioctanoylglycerol; 1-Capryloyl-2-capryloyl-3-capryloyl-glycerol; 1-Octanoyl-2-octanoyl-3-octanoyl-glycerol; 2-Ethylhexanoic acid, 1,2,3-propanetriyl ester; Axona; Caprylate triglyceride; Caprylate, 1,2,3-propanetriyl ester; Caprylic acid triglyceride; Caprylic acid, 1,2,3-propanetriyl ester; Caprylic triglyceride; Caprylin; Glycerin tricaprylate; Glycerin tricaprylic acid; Glycerol tricaprylate; Glycerol tricaprylic acid; Glycerol trioctanoate; Glycerol trioctanoic acid; Glycerol trioctanoin; Glyceryl tricaprylate; Glyceryl tricaprylic acid; Glyceryl trioctanoate; Octanoate triglyceride', Octanoate, 1,1',1''-(1,2,3-propanetriyl) ester, 'Octanoate, 1,2,3-propanetriyl ester; Octanoic acid triglyceride', Octanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, 'Octanoic acid, 1,2,3-propanetriyl ester; Octanoic acid, 1,2,3- propanetriyl ester; Panasate 800; TAG(24:0); TAG(8:0/8:0/8:0); TG(24:0); TG(8:0/8:0/8:0); Tracylglycerol(24:0); Tracylglycerol(8:0/8:0/8:0); Triacylglycerol; Tricaprilin; Tricaprylic glyceride; Tricaprylin; Tricapryloylglycerol; Tricaprylyl glycerin; Triethylhexanoin; Triglyceride; Trioctanoin; Trioctanoylglyceride; Trioctanoylglycerol
Source Endogenous;Food;Carcinogenic Potency;Cosmetic
Structure Type   Triradylcglycerols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerolipids
Triradylcglycerols
PubChem CID
10850
HMDB ID
HMDB0011187
Formula
C27H50O6
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C13044
DrugBank ID
DB12176
ChEBI ID
76978
FooDB ID
FDB003135
Physicochemical Properties Molecular Weight 470.7 Topological Polar Surface Area 78.9
XlogP 8.9 Complexity 461
Heavy Atom Count 33 Rotatable Bond Count 26
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count 6
Function
TG(8:0/8:0/8:0) belongs to the family of triradyglycerols, which are glycerolipids lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified. Their general formula is [R1]OCC(CO[R2])O[R3]. TG(8:0/8:0/8:0) is made up of one octanoyl(R1), one octanoyl(R2), and one octanoyl(R3).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sugar transporter (ST)
            Glucose transporter type 3 (GLUT-3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (GLUT3+/-) of Slc2a3
                      Induced Change TG(8:0/8:0/8:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that mutation (GLUT3+/-) of Slc2a3 leads to the increase of TG(8:0/8:0/8:0) levels compared with control group.
      Translocases (EC 7)
            ATP-binding cassette A5 (ABCA5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Abca5
                      Induced Change TG(8:0/8:0/8:0) concentration: increase (FC = 2.5)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Abca5 leads to the increase of TG(8:0/8:0/8:0) levels compared with control group.
References
1 Glucose transporter isoform-3-null heterozygous mutation causes sexually dimorphic adiposity with insulin resistance. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1144-51.
2 Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun. 2010 May 7;395(3):387-94.

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