Details of Protein

General Information of Protein (ID: PRT00709)
Name Urate anion exchanger 1 (URAT1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Renal-specific transporter; RST; Urate anion exchanger 1; Slc22a12; Urat1
Gene Name Slc22a12 Gene ID
20521
UniProt ID
Q8CFZ5
Family Organic ion transporter (OIT)
TC Number   TC: 2.A.1.19.14  (Click to Show/Hide the Complete TC Tree)
The Major Facilitator Superfamily (MFS)
The Organic Cation Transporter (OCT) Family (The SLC22A family including OCT1-3, OCTN1-3 and OAT1-5 of H. sapiens)
TC: 2.A.1.19.14
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MAFPELLDRVGGLGRFQLFQTVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQ
ASIPGDLGPDVLLAVSIPPGPDQQPHQCLRFRQPQWQLTESNATATNWSDAATEPCEDGW
VYDHSTFRSTIVTTWDLVCNSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSY
LLVSVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPLVMTLNALG
FSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQ
RVAAVNRRKAEGDTLTMEVLRSAMEEEPSRDKAGASLGTLLHTPGLRHRTIISMLCWFAF
GFTFYGLALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRFCQVSFLVLPGLCI
LSNILVPHGMGVLRSALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGA
MLGPLVRLLGVYGSWMPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSVKKVTH
DTPDGSILMSTRL
Function Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organoheterocyclic compounds
            Uric acid Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Slc22a12
                      Induced Change Uric acid concentration: increase (FC = 1.50)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Adrenomedullary hyperfunction [ICD-11: 5A75]
                      Details It is reported that overexpression of Slc22a12 leads to the increase of uric acid levels compared with control group.
References
1 Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002 May 23;417(6887):447-52.

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