| Regulating Pair |
| Introduced Variation |
Overexpression of Slc22a12 |
Protein Info
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| Induced Change |
Uric acid concentration: increase (FC = 1.50) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of uric acid concentration after Slc22a12 overexpression through 3H- or 14C-labeled amino acids assay. |
| Disease Status |
Adrenomedullary hyperfunction |
ICD-11: 5A75 |
| Organ/Tissue/Cell Line |
Xenopus oocytes |
N.A. |
| Subcellular Location |
Membrane (Cell membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that overexpression of Slc22a12 leads to the increase of uric acid levels compared with control group in xenopus oocytes. |
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| References |
| 1 |
Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002 May 23;417(6887):447-52.
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