Details of Protein

General Information of Protein (ID: PRT00675)
Name Lysophosphatidic acid receptor 5 (LPAR5)
Synonyms   Click to Show/Hide Synonyms of This Protein
LPA receptor 5; LPA-5; G-protein coupled receptor 92; G-protein coupled receptor 93; LPAR5; GPR92; GPR93
Gene Name LPAR5 Gene ID
57121
UniProt ID
Q9H1C0
Family GPCR rhodopsin (GPCR-1)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MLANSSSTNSSVLPCPDYRPTHRLHLVVYSLVLAAGLPLNALALWVFLRALRVHSVVSVY
MCNLAASDLLFTLSLPVRLSYYALHHWPFPDLLCQTTGAIFQMNMYGSCIFLMLINVDRY
AAIVHPLRLRHLRRPRVARLLCLGVWALILVFAVPAARVHRPSRCRYRDLEVRLCFESFS
DELWKGRLLPLVLLAEALGFLLPLAAVVYSSGRVFWTLARPDATQSQRRRKTVRLLLANL
VIFLLCFVPYNSTLAVYGLLRSKLVAASVPARDRVRGVLMVMVLLAGANCVLDPLVYYFS
AEGFRNTLRGLGTPHRARTSATNGTRAALAQSERSAVTTDATRPDAASQGLLRPSDSHSL
SSFTQCPQDSAL
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Lipids and lipid-like molecules
            Farnesyl pyrophosphate Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Farnesyl pyrophosphate addition (24 hours)
                      Induced Change LPAR5 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that farnesyl pyrophosphate addition causes the increase of LPAR5 protein activity compared with control group.
      Organic acids and derivatives
            N-Arachidonoylglycine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation N-Arachidonoylglycine addition (24 hours)
                      Induced Change LPAR5 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that N-arachidonoylglycine addition causes the increase of LPAR5 protein activity compared with control group.
References
1 Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19;284(25):17304-17319.

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