Details of Metabolite

General Information of MET (ID: META00039)
Name Farnesyl pyrophosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2E,6E)-Farnesol diphosphate; (2E,6E)-Farnesol diphosphoric acid; (2E,6E)-Farnesyl diphosphate; (2E,6E)-Farnesyl diphosphoric acid; (2E,6E)-Farnesyl pyrophosphate; (2E,6E)-Farnesyl pyrophosphoric acid; (all-e)-Farnesyl diphosphate; (all-e)-Farnesyl diphosphoric acid; (e,e)-Farnesyl diphosphate; (e,e)-Farnesyl pyrophosphate; (e,e)-Farnesyl pyrophosphoric acid; 2-trans,6-trans-Farnesyl diphosphate; 2-trans,6-trans-Farnesyl diphosphoric acid; 2-trans,6-trans-Farnesyl pyrophosphate; 2-trans,6-trans-Farnesyl pyrophosphoric acid; Farnesyl diphosphate; Farnesyl diphosphoric acid; Farnesyl pyrophosphate, (Z,Z)-isomer; Farnesyl pyrophosphate, (Z,e)-isomer; Farnesyl pyrophosphate, (e,Z)-isomer; Farnesyl pyrophosphate, (e,e)-isomer; Farnesyl pyrophosphoric acid; Farnesyl-PP; Farnesylpyrophosphate; all-trans-Farnesyl pyrophosphate; all-trans-Farnesyl pyrophosphoric acid; trans,trans-Farnesyl diphosphate; trans,trans-Farnesyl diphosphoric acid; trans-Farnesyl pyrophosphate; trans-trans-Farnesyl diphosphate; trans-trans-Farnesyl diphosphoric acid; trans-trans-Farnesyl pyrophosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Prenol lipids;Food;Drug;TCM Ingredients;Microbial
Structure Type   Sesquiterpenoids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Prenol lipids
Sesquiterpenoids
PubChem CID
445713
HMDB ID
HMDB0000961
Formula
C15H28O7P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00448
DrugBank ID
DB07780
ChEBI ID
17407
FooDB ID
FDB022339
ChemSpider ID
393270
METLIN ID
403
Physicochemical Properties Molecular Weight 382.33 Topological Polar Surface Area 113
XlogP 2.6 Complexity 568
Heavy Atom Count 24 Rotatable Bond Count 11
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulated by This Metabolite
      GPCR rhodopsin (GPCR-1)
            Lysophosphatidic acid receptor 5 (LPAR5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Farnesyl pyrophosphate addition (24 hours)
                      Induced Change LPAR5 protein activity levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that farnesyl pyrophosphate addition causes the increase of LPAR5 protein activity compared with control group.
References
1 Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19;284(25):17304-17319.

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