Details of Protein

General Information of Protein (ID: PRT00049)
Name Nuclear receptor coactivator 2 (NCOA2)
Synonyms   Click to Show/Hide Synonyms of This Protein
NCoA-2; Class E basic helix-loop-helix protein 75; bHLHe75; Transcriptional intermediary factor 2; hTIF2; NCOA2; BHLHE75; SRC2; TIF2
Gene Name NCOA2 Gene ID
10499
UniProt ID
Q15596
Family Transcriptional coactivator (TC)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG
QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL
SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS
LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS
STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII
NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA
VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG
PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL
DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ
AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ
QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ
RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT
PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN
TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG
NLFPNQLPGMDMIKQEGDTTRKYC
Structure
1GWQ ; 1GWR ; 1M2Z ; 1MV9 ; 1MVC ; 1MZN ; 1P93 ; 1T63 ; 1T65 ; 1UHL ; 1YOK ; 1ZDT ; 1ZDU ; 1ZKY ; 2AO6 ; 2B1V ; 2B1Z ; 2B23 ; 2FAI ; 2G44 ; 2G5O ; 2LDC ; 2P15 ; 2P1T ; 2P1U ; 2P1V ; 2Q7J ; 2Q7L ; 2YJD ; 2ZXZ ; 2ZY0 ; 3A9E ; 3CLD ; 3DZU ; 3DZY ; 3E00 ; 3E7C ; 3E94 ; 3ERD ; 3FUG ; 3GN8 ; 3K22 ; 3K23 ; 3KWY ; 3KYT ; 3L0E ; 3L0J ; 3L0L ; 3O1D ; 3O1E ; 3OAP ; 3OZJ ; 3PCU ; 3PLZ ; 3Q95 ; 3R5M ; 3UP0 ; 3UP3 ; 4CSJ ; 4DOS ; 4E2J ; 4FHH ; 4FHI ; 4IA1 ; 4IA2 ; 4IA3 ; 4IA7 ; 4IQR ; 4IU7 ; 4IUI ; 4IV2 ; 4IV4 ; 4IVW ; 4IVY ; 4IW6 ; 4IW8 ; 4IWC ; 4IWF ; 4K4J ; 4K6I ; 4M8E ; 4M8H ; 4NIE ; 4NQA ; 4OC7 ; 4P6W ; 4P6X ; 4PLD ; 4PLE ; 4POH ; 4POJ ; 4PP3 ; 4PP5 ; 4PP6 ; 4PPP ; 4PPS ; 4PXM ; 4Q0A ; 4Q13 ; 4QE6 ; 4QE8 ; 4RFW ; 4RMC ; 4RMD ; 4RME ; 4RUO ; 4UDC ; 4UDD ; 4WG0 ; 4ZN7 ; 4ZN9 ; 4ZNH ; 4ZNS ; 4ZNT ; 4ZNU ; 4ZNV ; 4ZNW ; 4ZO1 ; 4ZSH ; 5APH ; 5APJ ; 5DI7 ; 5DID ; 5DIE ; 5DIG ; 5DK9 ; 5DKB ; 5DKE ; 5DKG ; 5DKS ; 5DL4 ; 5DLR ; 5DMC ; 5DMF ; 5DP0 ; 5DRJ ; 5DRM ; 5DTV ; 5DU5 ; 5DUE ; 5DUG ; 5DUH ; 5DVS ; 5DVV ; 5DWE ; 5DWG ; 5DWI ; 5DWJ ; 5DX3 ; 5DXB ; 5DXE ; 5DXG ; 5DXK ; 5DXM ; 5DXP ; 5DXQ ; 5DXR ; 5DY8 ; 5DYB ; 5DYD ; 5DZ0 ; 5DZ1 ; 5DZ3 ; 5DZH ; 5DZI ; 5E0W ; 5E0X ; 5E14 ; 5E15 ; 5E19 ; 5E1C ; 5EC9 ; 5EGV ; 5EHJ ; 5EI1 ; 5EIT ; 5G3J ; 5G42 ; 5G43 ; 5G44 ; 5G45 ; 5G46 ; 5G5W ; 5H1E ; 5HYR ; 5I4V ; 5IAW ; 5ICK ; 5KCC ; 5KCD ; 5KCE ; 5KCF ; 5KCT ; 5KCU ; 5KCW ; 5KD9 ; 5KR9 ; 5KRA ; 5KRC ; 5KRF ; 5KRH ; 5KRI ; 5KRJ ; 5KRK ; 5KRL ; 5KRM ; 5KRO ; 5L11 ; 5LGA ; 5LYQ ; 5MK4 ; 5NFP ; 5NFT ; 5NI5 ; 5NI7 ; 5NI8 ; 5NIB ; 5Q17 ; 5SYZ ; 5T1Z ; 5TLD ; 5TLF ; 5TLG ; 5TLL ; 5TLM ; 5TLO ; 5TLP ; 5TLT ; 5TLU ; 5TLV ; 5TLX ; 5TLY ; 5TM1 ; 5TM2 ; 5TM3 ; 5TM4 ; 5TM5 ; 5TM6 ; 5TM7 ; 5TM8 ; 5TM9 ; 5TML ; 5TMM ; 5TMO ; 5TMQ ; 5TMR ; 5TMS ; 5TMT ; 5TMU ; 5TMV ; 5TMW ; 5TMZ ; 5TN1 ; 5TN3 ; 5TN4 ; 5TN5 ; 5TN6 ; 5TN7 ; 5TN8 ; 5U2D ; 5UAN ; 5VB3 ; 5VB5 ; 5VB6 ; 5VB7 ; 5VQK ; 5VQL ; 5WGQ ; 5WZX ; 5XPL ; 5Y1J ; 5Y49 ; 5YP5 ; 5YXB ; 5YXD ; 5YXJ ; 5YXL ; 5Z12 ; 6CZN ; 6D0F ; 6EL6 ; 6EL7 ; 6EL9 ; 6ESN ; 6KKB ; 6KKE ; 6KNU ; 6KNV ; 6KNW ; 6LB4 ; 6LB5 ; 6LB6 ; 6LIT ; 6OQX ; 6OQY ; 6OR1 ; 6R7A ; 6R7J ; 6R7K ; 6SJM ; 6STI ; 6VC2 ; 6VIF ; 7A77 ; 7A78 ; 7A79 ; 7B88 ; 7D42 ; 7JHD
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer.
Regulatory Network
Full List of Metabolite(s) Regulated by This Protein
      Organic acids and derivatives
            Lactic acid Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of NCOA2
                      Induced Change Lactic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Uterine cancer [ICD-11: 2C76]
                      Details It is reported that knockdown of NCOA2 leads to the decrease of lactic acid levels compared with control group.
      Organic oxygen compounds
            D-Ribose 5-phosphate Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of NCOA2
                      Induced Change D-Ribose 5-phosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Uterine cancer [ICD-11: 2C76]
                      Details It is reported that knockdown of NCOA2 leads to the decrease of D-Ribose 5-phosphate levels compared with control group.
            D-Ribulose 5-phosphate Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of NCOA2
                      Induced Change D-Ribulose 5-phosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Uterine cancer [ICD-11: 2C76]
                      Details It is reported that knockdown of NCOA2 leads to the decrease of D-Ribulose 5-phosphate levels compared with control group.
References
1 Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 Sep 3;8(1):13134.

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