| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of NCOA2 |
Protein Info
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| Induced Change |
Lactic acid concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of L-lactic acid concentration after NCOA2 knockdown through liquid chromatographymass spectrometry (LC-MS) based metabolomics. |
| Disease Status |
Uterine cancer |
ICD-11: 2C76 |
| Organ/Tissue/Cell Line |
N.A. |
Endometrium |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of NCOA2 leads to the decrease of lactic acid levels compared with control group. |
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| References |
| 1 |
Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 Sep 3;8(1):13134.
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