Details of Metabolite

General Information of MET (ID: META00281)
Name D-Ribulose 5-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
D-Erythro-pent-2-ulose 5-(dihydrogen phosphate); D-Erythro-pent-2-ulose 5-(dihydrogen phosphoric acid); D-Ribulose 5-phosphoric acid; Ribulose 5-phosphate; Ribulose 5-phosphate, (D)-isomer; Ribulose 5-phosphate, (L)-isomer
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
439184
HMDB ID
HMDB0000618
Formula
C5H11O8P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=439184"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00199
ChEBI ID
17363
FooDB ID
FDB022145
ChemSpider ID
388327
Physicochemical Properties Molecular Weight 230.11 Topological Polar Surface Area 145
XlogP -3.7 Complexity 234
Heavy Atom Count 14 Rotatable Bond Count 6
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Function
D-Ribulose 5-phosphate is a metabolite in the following pathways: pentose phosphate pathway, pentose and glucuronate interconversions, and riboflavin metabolism (KEGG).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change D-Ribulose 5-phosphate concentration: increase (FC = 2.40)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of D-Ribulose 5-phosphate levels compared with control group.
      Transcriptional coactivator (TC)
            Nuclear receptor coactivator 2 (NCOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockdown (siRNA) of NCOA2
                      Induced Change D-Ribulose 5-phosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Uterine cancer [ICD-11: 2C76]
                      Details It is reported that knockdown of NCOA2 leads to the decrease of D-Ribulose 5-phosphate levels compared with control group.
References
1 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.
2 Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 Sep 3;8(1):13134.

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