| Regulating Pair |
| Introduced Variation |
Knockout of Pla2g10 |
Protein Info
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| Induced Change |
Prostaglandin E2 concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of prostaglandin E2 concentration after Pla2g10 knockout through kit detection. |
| Disease Status |
Acute asthma exacerbations |
ICD-11: CA23 |
| Organ/Tissue/Cell Line |
N.A. |
Bal Fluid |
| Subcellular Location |
Secreted; Lysosome; Cytoplasm (Cytoplasmic vesicle; Secretory vesicle; Acrosome) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Pla2g10 leads to the decrease of prostaglandin E2 levels compared with control group. |
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| References |
| 1 |
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007 Apr 16;204(4):865-77.
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