| Regulating Pair |
| Introduced Variation |
Knockout of Ormdl3 |
Protein Info
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| Induced Change |
Ceramide(d18:0/18:0) concentration: increase |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of Cer(d18:0/18:0) concentration after Ormdl3 knockout through HPLC-tandem MS based metabolomics. |
| Disease Status |
White matter disorders |
ICD-11: 8A45 |
| Organ/Tissue/Cell Line |
N.A. |
Brain |
| Subcellular Location |
Endoplasmic reticulum (Endoplasmic reticulum membrane) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Ormdl3 leads to the increase of ceramide(d18:0/18:0) levels compared with control group. |
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| References |
| 1 |
The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice. Elife. 2019 Dec 27;8:e51067.
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