Details of Metabolite

General Information of MET (ID: META00872)
Name Ceramide(d18:0/18:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
C18-(Dihydro)ceramide; C18-Dihydroceramide; C18DH Cer; Cer(d18:0/18:0); Ceramide; Ceramide(D18:0/18:0); DHC-a 18:0/18:0; Dihydroceramide; N-(Octadecanoyl)-D-erythro-sphinganine; N-(Octadecanoyl)-dihydroceramide; N-(Octadecanoyl)-dihydrosphingosine; N-(Octadecanoyl)-sphinganine; N-(Octodecanoyl)-sphinganine; N-(Stearoyl)-dihydroceramide; N-Octodecanoyldihydroceramide; N-Octodecanoyldihydrosphingosine; N-Stearoyl-sphinganine; N-Stearoyldihydroceramide; N-Stearoyldihydrosphingosine; N-Stearoylsphinganine
Source Endogenous;Sphingolipids;Food
Structure Type   Ceramides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Ceramides
PubChem CID
5283573
HMDB ID
HMDB0011761
Formula
C36H73NO3
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
67033
FooDB ID
FDB028431
ChemSpider ID
4446686
Physicochemical Properties Molecular Weight 568 Topological Polar Surface Area 69.6
XlogP 14.5 Complexity 498
Heavy Atom Count 40 Rotatable Bond Count 33
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis. Is key in the biosynthesis of glycosphingolipids and gangliosides.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transmembrane protein (TMEM)
            ORM1-like protein 3 (ORMDL3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Ormdl3
                      Induced Change Ceramide(d18:0/18:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status White matter disorders [ICD-11: 8A45]
                      Details It is reported that knockout of Ormdl3 leads to the increase of ceramide(d18:0/18:0) levels compared with control group.
References
1 The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice. Elife. 2019 Dec 27;8:e51067.

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