| Regulating Pair |
| Introduced Variation |
Knockout of Hmgn5 |
Protein Info
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| Induced Change |
Creatine concentration: decrease (FC = 0.58) |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of creatine concentration after Hmgn5 knockout through UPLC-ESI-QTOF-MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
N.A. |
Liver |
| Subcellular Location |
Nucleus |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
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| Details |
It is reported that knockout of Hmgn5 leads to the decrease of creatine levels compared with control group. |
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| References |
| 1 |
Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.
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