| Regulating Pair |
| Introduced Variation |
Knockdown (siRNA) of DAND5 |
Protein Info
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| Induced Change |
Sphingosine 1-phosphate concentration: decrease |
Metabo Info
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| Summary |
Introduced Variation
Induced Change
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| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of sphingosine 1-phosphate concentration after DAND5 knockdown through ESI/MS/MS based metabolomics. |
| Disease Status |
Healthy individual |
| Organ/Tissue/Cell Line |
Hela-T-Rex cells (Human cervical cancer cells) |
Cervix |
| Subcellular Location |
Secreted |
| Tested Species |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Details |
It is reported that knockdown of DAND5 leads to the decrease of sphingosine 1-phosphate levels compared with control group in Hela-T-Rex cells. |
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| References |
| 1 |
Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J. 2006 Sep;20(11):1813-25.
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