| Regulating Pair |
| Introduced Variation |
Knockout of Ppargc1a |
Protein Info
|
| Induced Change |
Ergothioneine concentration: decrease |
Metabo Info
|
| Summary |
Introduced Variation
Induced Change
|
|
|
|
|
|
|
|
| Full List of Experiment(s) Validating This Regulating Pair |
| Details of Experiment for Validating This Pair |
[1] |
| Method |
Quantifying the change of ergothioneine concentration after Ppargc1a knockout through Non-targeted LC-MS based metabolomics. |
| Disease Status |
Congestive heart failure |
ICD-11: BD10 |
| Organ/Tissue/Cell Line |
Mouse Cardiomyocytes |
Heart |
| Subcellular Location |
Nucleus (PML body) |
| Tested Species |
Species: Mus musculus (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Rodentia
Family: Muridae
Genus: Mus
Species: Mus musculus
|
| Details |
It is reported that knockout of Ppargc1a leads to the decrease of ergothioneine levels compared with control group in mouse Cardiomyocytes. |
|
|
|
|
|
|
|
| References |
| 1 |
Heart specific PGC-1 deletion identifies metabolome of cardiac restricted metabolic heart failure. Cardiovasc Res. 2019 Jan 1;115(1):107-118.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.
